Continued dysregulation of the B cell lineage promotes multiple sclerosis activity despite disease modifying therapies [version 1; peer review: 1 approved with reservations]

A clear understanding of the origin and role of the different subtypes of the B cell lineage involved in the activity or remission of multiple sclerosis (MS) is important for the treatment and follow-up of patients living with this disease. B cells, however, are dynamic and can play an anti-inflamma...

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Bibliographic Details
Published in:F1000 research 2021, Vol.10, p.1305
Main Authors: Londoño, Ana C., Mora, Carlos A.
Format: Article
Language:English
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Summary:A clear understanding of the origin and role of the different subtypes of the B cell lineage involved in the activity or remission of multiple sclerosis (MS) is important for the treatment and follow-up of patients living with this disease. B cells, however, are dynamic and can play an anti-inflammatory or pro-inflammatory role, depending on their milieu. Depletion of B cells has been effective in controlling the progression of MS, but it can have adverse side effects. A better understanding of the role of the B cell subtypes, through the use of surface biomarkers of cellular activity with special attention to the function of memory and regulatory B cells (Bregs), will be necessary in order to offer specific treatments without inducing undesirable effects.
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.74506.1