Effect of N-acetylcysteine on 12C6+ ion Irradiation-induced Lymphocytes DNA Damages and Immunity Changes in Mice

The aims of present study are to estimate the biological risks to the immunity of mice exposed to heavy ion radiation and to investigate the effect of N-acetylcysteine (NAC) on 12C6+ ion irradiation-induced lymphocyte DNA damage. Results showed that in the brine group, the levels of lymphocyte DNA d...

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Bibliographic Details
Published in:JOURNAL OF RADIATION RESEARCH 2009, Vol.50 (6), p.567-571
Main Authors: XIE, Yi, ZHANG, Hong, HAO, Ji-Fang, QIU, Rong
Format: Article
Language:English
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Summary:The aims of present study are to estimate the biological risks to the immunity of mice exposed to heavy ion radiation and to investigate the effect of N-acetylcysteine (NAC) on 12C6+ ion irradiation-induced lymphocyte DNA damage. Results showed that in the brine group, the levels of lymphocyte DNA damage and MN, thymocytes G2/M phase arrest and apoptosis percentages (except for activity of NK cells) were up at each time point. A time-response curve for MN and DNA damage appeared in the NAC group. We found that whole-body 12C6+ ion irradiation at a dose of 4 Gy could:induce lymphocyte DNA double-strand breaks (DSBs);immunocytes DSBs may lead to acute effects on immunity;and 200 mg/kgNAC showed significant protection against radiation harm.
ISSN:0449-3060
1349-9157
DOI:10.1269/jrr.09047