Influence of seed extract of Syzygium Cumini (Jamun) on mice exposed to different doses of gamma-radiation

The radioprotective activity of the hydroalcoholic extract of jamun seeds (SCE) was studied in mice exposed to different doses of gamma radiation. The mice were injected with 0, 5, 10, 20, 40, 60, 80, 100, 120, 140 or 160 mg/kg body weight of SCE, before exposure to 10 Gy of gamma radiation, to sele...

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Bibliographic Details
Published in:Journal of radiation research 2005, Vol.46 (1), p.59-65
Main Authors: Jagetia, Ganesh Chandra, Baliga, Manjeshwar Shrinath, Venkatesh, Ponemone
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Gamma Rays - adverse effects
Injections, Intraperitoneal
Longevity - radiation effects
Male
Mice
Phytotherapy - methods
Plant Extracts - administration & dosage
Radiation Dosage
Radiation Injuries - etiology
Radiation Injuries - prevention & control
Radiation Tolerance - drug effects
Radiation-Protective Agents - administration & dosage
Seeds - chemistry
Survival Analysis
Syzygium - chemistry
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Summary:The radioprotective activity of the hydroalcoholic extract of jamun seeds (SCE) was studied in mice exposed to different doses of gamma radiation. The mice were injected with 0, 5, 10, 20, 40, 60, 80, 100, 120, 140 or 160 mg/kg body weight of SCE, before exposure to 10 Gy of gamma radiation, to select the optimum dose of radiation protection. The 80 mg/kg SCE was found to offer highest protection, therefore, further studies were carried out using this dose. The drug was more effective when administered through the intraperitoneal route at equimolar doses than the oral route. Since higher survival was observed for the i.p. route (50%), than the oral route (29.2%), all other studies were carried out by injecting SCE intraperitoneally. The mice treated with 80 mg/kg body weight SCE intraperitoneally before exposure to 6, 7, 8, 9, 10 and 11 Gy of gamma radiation showed reduction in the symptoms of radiation sickness and mortality at all exposure doses and caused a significant increase in the animal survival when compared with the concurrent double distilled water (DDW) + irradiation group. The SCE treatment protected mice against the gastrointestinal as well as bone marrow deaths and the DRF was found to be 1.24.
ISSN:0449-3060
1349-9157
DOI:10.1269/jrr.46.59