Absorption of Proteoglycan via Clathrin-Mediated Endocytosis in the Small Intestine of Rats

The mechanism underlying proteoglycan (PG) absorption in the intestine is not clear. Hence we analyzed the transport of salmon PG in the rat jejunum, ileum, and colon by the everted-sac method. The jejunum showed the largest capacity for PG transport. Jejunal transport of PG was also greater than th...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2013, Vol.77 (3), p.654-656
Main Authors: TSUCHIYA, Yo, TOMITA, Masahiro, TSUBOI, Makoto, TAKAHASHI, Tatsuji, YONEZUKA, Masato, KIKUCHI, Satomi, NAGASAWA, Sanae, KUMAZAWA, Airi, KUBOTA, Junko
Format: Article
Language:English
Subjects:
Animals
clathrin
Clathrin - metabolism
Endocytosis
Intestinal Absorption
Intestine, Small - metabolism
jejunum
proteoglycan
Proteoglycans - metabolism
Rats
Salmonidae
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Summary:The mechanism underlying proteoglycan (PG) absorption in the intestine is not clear. Hence we analyzed the transport of salmon PG in the rat jejunum, ileum, and colon by the everted-sac method. The jejunum showed the largest capacity for PG transport. Jejunal transport of PG was also greater than that of chondroitin A and C. An inhibitor of clathrin-mediated endocytosis reduced jejunal PG transport. We conclude that intestinal PG transport is highest in the jejunum, and is partially dependent on clathrin-mediated endocytosis.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.120773