Synthetic and Structure-Activity Relationship Studies on Bioactive Natural Products

This review summarizes our research into the synthesis and structure-activity relationships of epolactaene, neoechinulin A, plakevulin A, pseudodeflectusin and ustusorane C. These natural products are attractive in view of their apoptosis-inducing activity, cytoprotective activity against peroxynitr...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2013, Vol.77 (3), p.446-454
Main Author: KURAMOCHI, Kouji
Format: Article
Language:English
Subjects:
Animals
Biological Products - chemical synthesis
Biological Products - chemistry
Biological Products - pharmacology
Humans
natural product
Organic Chemicals - chemical synthesis
Organic Chemicals - chemistry
Organic Chemicals - pharmacology
Structure-Activity Relationship
synthesis
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Summary:This review summarizes our research into the synthesis and structure-activity relationships of epolactaene, neoechinulin A, plakevulin A, pseudodeflectusin and ustusorane C. These natural products are attractive in view of their apoptosis-inducing activity, cytoprotective activity against peroxynitrite, inhibitory activity against DNA polymerases, and cytotoxicity in cancer cells.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.120884