Stimulation of nerve growth factor (NGF) synthesis by tryptophan and its metabolites in cultured mouse astroglial cells

Effects of l-tryptophan and its metabolites were evaluated on synthesis of nerve growth factor (NGF) in cultured mouse astroglial cells. l-Tryptophan stimulated NGF production in a dose-dependent fashion. Serotonin and quinolinic acid slightly increased NGF synthesis. l-Kynurenine had a marked stimu...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1994, Vol.58 (11), p.2116-2117
Main Authors: Nakano, K. (Nagoya Univ. (Japan)), Kondo, H, Hattori, M, Tsubouchi, S, Furukawa, S
Format: Article
Language:English
Subjects:
ALIMENTOS
Analytical, structural and metabolic biochemistry
ANIMAL GROWTH PROMOTERS
Biological and medical sciences
FOODS
Fundamental and applied biological sciences. Psychology
MICE
NERVOUS SYSTEM DISEASES
PRODUIT ALIMENTAIRE
PROMOTEUR DE CROISSANCE ANIMALE
PROMOTORES DEL CRECIMIENTO ANIMAL
Protein hormones. Growth factors. Cytokines
Proteins
RATON
SOURIS
TRASTORNOS DEL SISTEMA NERVIOSO
TRIPTOFANO
TROUBLE DU SYSTEME NERVEUX
TRYPTOPHAN
TRYPTOPHANE
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Summary:Effects of l-tryptophan and its metabolites were evaluated on synthesis of nerve growth factor (NGF) in cultured mouse astroglial cells. l-Tryptophan stimulated NGF production in a dose-dependent fashion. Serotonin and quinolinic acid slightly increased NGF synthesis. l-Kynurenine had a marked stimulatory effect on NGF synthesis at a dose of 100 μm. In contrast, kynurenic acid had no effect.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.58.2116