Increase in the Level of mRNA for 3-Hydroxyanthranilate 3,4-Dioxygenase in Brain of Epilepsy-prone EI Mice

We had shown that production of quinolinic acid is high in the brain of epilepsy-prone El mice and that this is due to an increase in the activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO, EC 1.13.11.6). We demonstrated here that the level of mRNA for 3-HAO was markedly increased in the brain...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1995-01, Vol.59 (11), p.2191-2192
Main Authors: Nakagawa, Yukinori, Asai, Hiroshi, Kitoh, Junzoh, Mori, Hitoshi, Nakano, Kiwao
Format: Article
Language:English
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Summary:We had shown that production of quinolinic acid is high in the brain of epilepsy-prone El mice and that this is due to an increase in the activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO, EC 1.13.11.6). We demonstrated here that the level of mRNA for 3-HAO was markedly increased in the brain of El mice.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.59.2191