Proposed Two-molecule Intercalation between Neighboring Base Pairs of DNA

DNA intercalation of 9-aminoacridine and its derivatives was evaluated by the UV -VIS absorption-Scatchard plot technique, and it was suggested that two molecules of 9-amino-2,7-dibromoacridine were located between neighboring base pairs of DNA.

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1995, Vol.59 (5), p.960-961
Main Authors: Tomosaka, Hideyuki, Anzai, Kentaro, Omata, Saburo
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antineoplastic agents
Antiparasitic agents
Biological and medical sciences
General aspects
Medical sciences
Pharmacology. Drug treatments
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Description
Summary:DNA intercalation of 9-aminoacridine and its derivatives was evaluated by the UV -VIS absorption-Scatchard plot technique, and it was suggested that two molecules of 9-amino-2,7-dibromoacridine were located between neighboring base pairs of DNA.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.59.960