Effect of exposure to high isoflavone-containing diets on prenatal and postnatal offspring mice

Isoflavone (IF), a type of phytoestrogen, has multiple beneficial effects, but too much phytoestrogen can have adverse effects on offspring. To examine whether chronic exposure to high IF has adverse effects on reproductive development, mice offspring were exposed to IF through dietary administratio...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2006-12, Vol.70 (12), p.2874-2882
Main Authors: Takashima Sasaki, K.(Chiba Univ. (Japan)), Komiyama, M, Adachi, T, Sakurai, K, Kato, H, Iguchi, T, Mori, C
Format: Article
Language:English
Subjects:
ADMINISTRACION
ADMINISTRATION
Animals
Base Sequence
Biological and medical sciences
Body Weight - drug effects
DIET
DIETA
DNA Primers
Feeding Behavior - drug effects
Female
FEMALES
FEMELLE
FITOESTROGENOS
FLAVONOIDE
FLAVONOIDES
FLAVONOIDS
FOLICULOS OVARICOS
FOLLICULE OVARIEN
Fundamental and applied biological sciences. Psychology
Genitalia, Female - drug effects
Genitalia, Female - growth & development
Genitalia, Male - drug effects
Genitalia, Male - growth & development
HEMBRA
isoflavone
Isoflavones - administration & dosage
Isoflavones - pharmacology
MACHO
MADUREZ SEXUAL
MALE
MALES
Maternal Exposure
MATURITE SEXUELLE
MICE
Mice, Inbred C57BL
multioocyte follicles
OVARIAN FOLLICLES
phytoestrogen
PHYTOESTROGENE
PHYTOOESTROGENS
Pregnancy
RATON
REGIME ALIMENTAIRE
Reverse Transcriptase Polymerase Chain Reaction
Sexual Maturation - drug effects
SEXUAL MATURITY
SOURIS
VAGIN
VAGINA
vaginal opening
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Summary:Isoflavone (IF), a type of phytoestrogen, has multiple beneficial effects, but too much phytoestrogen can have adverse effects on offspring. To examine whether chronic exposure to high IF has adverse effects on reproductive development, mice offspring were exposed to IF through dietary administration to dams during pregnancy and lactation and to the offspring directly after weaning until sacrifice. In male offspring, there was no difference between the IF group and controls; however, in female offspring in the IF group, remarkably earlier puberty and induction of multioocyte follicles on postnatal day (PND) 21 were observed. Gene expression levels of estrogen receptor beta decreased in the ovary and vagina on PND 21. These results suggest that chronic exposure to higher than normal levels of IF induces alterations in the reproductive development of female mice through an estrogenic effect.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.60278