Identification of a Soluble NADPH Oxidoreductase (BmNOX) with Antiviral Activites in the Gut Juice of Bombyx mori

Silkworms show high variability in silk quality and disease resistance. Attempts are on to combine the disease tolerance of multivoltine races and the silk quality of bivoltine races to generate new races with desirable phenotypic traits. We report the identification of a 26.5-kDa protein that is ov...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2007-01, Vol.71 (1), p.200-205
Main Authors: SELOT, Ruchita, KUMAR, Virendra, SHUKLA, Sunita, CHANDRAKUNTAL, Kumar, BRAHMARAJU, Mopidevi, DANDIN, SB, LALORAYA, Malini, KUMAR, Pradeep G.
Format: Article
Language:English
Subjects:
anti-viral
Biological and medical sciences
Bombyx mori
Fundamental and applied biological sciences. Psychology
NOX
silkworm
virus resistance
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Summary:Silkworms show high variability in silk quality and disease resistance. Attempts are on to combine the disease tolerance of multivoltine races and the silk quality of bivoltine races to generate new races with desirable phenotypic traits. We report the identification of a 26.5-kDa protein that is overexpressed in the gut juice of disease-resistant multivoltine races and that has anti-BmNPV activity. We have characterized this protein as a soluble NADH-oxidoreductase-like protein (BmNOX). Treatment of live BmNPV particles with BmNOX inhibited the capability of the viral particles to infect BmN cells in vitro.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.60450