Effects of Brewer's yeast cell wall on constipation and defecation in experimentally constipated rats

Brewer's yeast cell wall (BYC) was tested on constipated male Sprague-Dawley rats that had been induced by loperamide (2 mg/kg of body weight). The preventive effect of BYC on constipation was examined and compared with that of a non-fiber diet (NF) as the control. The dose-response of BYC and...

Full description

Saved in:
Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2001-04, Vol.65 (4), p.774-780
Main Authors: Nakamura, T. (Kirin Brewery Co. Ltd., Takasaki, Gunma (Japan). Applied Bioresearch Center), Agata, K, Mizutani, M, Iino, H
Format: Article
Language:English
Subjects:
Antidiarrheals - pharmacology
Biological and medical sciences
BREWERS' YEAST
Cathartics - pharmacology
Cell Wall - chemistry
CELL WALLS
constipation
Constipation - chemically induced
Constipation - drug therapy
DEFAECATION
defecation
Defecation - drug effects
Diet
Dietary Fiber
DIETARY FIBRES
DIGESTIVE DISORDERS
Eating - drug effects
Feces - chemistry
FEED INTAKE
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
INTESTINES
LABORATORY ANIMALS
Loperamide - pharmacology
rat
RATS
Saccharomyces cerevisiae - chemistry
Vertebrates: anatomy and physiology, studies on body, several organs or systems
VOLATILE FATTY ACIDS
Weight Gain - drug effects
yeast cell wall
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Brewer's yeast cell wall (BYC) was tested on constipated male Sprague-Dawley rats that had been induced by loperamide (2 mg/kg of body weight). The preventive effect of BYC on constipation was examined and compared with that of a non-fiber diet (NF) as the control. The dose-response of BYC and the effect on defecation by constipated experimental rats were also compared with the characteristics of cellulose diet (CE) group which served as a control. Defecation was observed to be greater by the rats fed with BYC than by those fed with NF or CE. The fecal water content and level of volatile fatty acids (VFA) in the cecal contents were likewise higher in the rats fed with BYC. These results indicate that the administration of BYC was effective for improving defecation and other parameters related to defecation. These favorable effects of BYC supplemented to the diet are attributed to the fermentation ability, water holding capacity and swelling force in the large intestine.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.65.774