Chinese hypertriglycerideamic subjects of different ages responded differently to consuming oil with medium- and long-chain fatty acids

• Published in: Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2009-08, Vol.73 (8), p.1711-1717
• Main Authors: Xue, C.(Chinese PLA General Hospital, Beijing (China)), Liu, Y, Wang, J, Zheng, Z, Zhang, Y, Zhang, R, Yu, X, Jin, H, Nosaka, N, Arai, C, Kasai, M, Aoyama, T, Wu, J
• Format: Article
• Language: English
• Subjects: ACIDE GRAS; ACIDOS GRASOS; ADIPOSE TISSUE; Adipose Tissue - drug effects; Adult; AGE; Age Distribution; Aged; Apolipoproteins - blood; Asian Continental Ancestry Group; Biological and medical sciences; BIOMETRIA; BIOMETRIE; BIOMETRY; BLOOD COMPOSITION; Blood Glucose - metabolism; blood triglyceride; body fat; Cholesterol - blood; COMPOSICION DE LA SANGRE; COMPOSITION DU SANG; Dietary Fats - pharmacology; EDAD; Energy Intake; FATTY ACIDS; Fatty Acids - chemistry; Female; Fundamental and applied biological sciences. Psychology; Humans; hypertriglyceridemia; Hypertriglyceridemia - blood; Hypertriglyceridemia - enzymology; Hypertriglyceridemia - physiopathology; Male; medium- and long-chain triacylglycerols; METABOLIC DISORDERS; Motor Activity; OVERWEIGHT; SOBREPESO; SURPOIDS; TEJIDO ADIPOSO; TISSU ADIPEUX; TRASTORNOS METABOLICOS; TRIGLICERIDOS; TRIGLYCERIDE; TRIGLYCERIDES; Triglycerides - blood; Triglycerides - chemistry; Triglycerides - pharmacology; TROUBLE DU METABOLISME
• ISSN: 0916-8451; 1347-6947
• DOI: 10.1271/bbb.80827

Two groups of Chinese hypertriacylglycerolemic subjects were recruited and randomized to medium- and long-chain triacylglycerols (MLCT) oil or long-chain triacylglycerols (LCT) oil. Two subgroups were divided by age at less or more 60 years in both groups. Both oils were consumed at 25-30 g daily for 8 weeks. Anthropometry, blood biochemicals, and computed tomography (CT) scanning were done at the initial and final times. In subjects of age less than 60 years on MLCT, the body weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-hip ratio (WHR), body fat, total fat area, and subcutaneous fat area were significantly lower than those of the initial values, and the change values in these indicators and visceral fat area lowered significantly as compared with those on LCT. The levels of apoB, apoA2, apoC2, and apoC3 decreased significantly, and the change in values in the levels of triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), apoA1, apoB, apoA2, apoC2, apoC3 were significantly lower on MLCT of age under 60 years as compared with those on LCT.