A Practical Approach for Solubility Enhancement of Leflunomide

Leflunomide is an anti-rheumatic medication. As it has low water solubility, it shows low absorption in gastrointestinal tract. The reported solubility of Leflunomide is approx 25.27 mcg/ml. Leflunomide comes under BCS Class II in which it has low solubility and high permeability. In this study, gel...

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Bibliographic Details
Published in:Oriental journal of chemistry 2023-10, Vol.39 (5), p.1386-1388
Main Authors: Bhandari, Yash, Rathore, Sunayana, Raghuwanshi, Vaishali, Sheikh, Shehnaz, Sharma, Yashmita, Dubey, Ishan
Format: Article
Language:English
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Summary:Leflunomide is an anti-rheumatic medication. As it has low water solubility, it shows low absorption in gastrointestinal tract. The reported solubility of Leflunomide is approx 25.27 mcg/ml. Leflunomide comes under BCS Class II in which it has low solubility and high permeability. In this study, gel entrapment technique is used to enhance the solubility of leflunomide. In this technique Hydroxy Propyl Methyl Cellulose and Ethyl Cellulose are used which are converted to gel with the addition of different organic solvent such as Ethanol, Chloroform, Di chloro Methane etc. The analyses of the samples are done by UV Spectrophotometer at 260nm. Results shows an increment in solubility of Leflunomide drug by gel entrapment technique and are found to be 5.23, 3.80, 3.05 and 2.64 times using HPMC+Chloroform, HPMC+Ethanol+ Dichloro methane, HPMC+Ethanol+Water, HPMC+Ethyl Cellulose+ Dichloro methane+ Water respectively.
ISSN:0970-020X
2231-5039
DOI:10.13005/ojc/390537