Carbamazepine--indinavir interaction causes antiretroviral therapy failure

OBJECTIVE: To report a case of antiretroviral therapy failure caused by an interaction between carbamazepine and indinavir. CASE SUMMARY: A 48-year-old HIV-positive white man was treated with antiretroviral triple therapy, consisting of indinavir, zidovudine, and lamivudine. His HIV-RNA (viral load)...

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Bibliographic Details
Published in:The Annals of pharmacotherapy 2000-04, Vol.34 (4), p.465-470
Main Authors: Hugen, PW, Burger, DM, Brinkman, K, ter Hofstede, HJ, Schuurman, R, Koopmans, PP, Hekster, YA
Format: Article
Language:English
Subjects:
Anti-HIV Agents - blood
Anti-HIV Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Anticonvulsants - therapeutic use
Antiviral agents
Biological and medical sciences
Carbamazepine - therapeutic use
Cytochrome P-450 Enzyme Inhibitors
Drug Interactions
Drug Therapy, Combination
HIV - drug effects
HIV Infections - drug therapy
Humans
Indinavir - blood
Indinavir - therapeutic use
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Seizures - drug therapy
Treatment Failure
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Summary:OBJECTIVE: To report a case of antiretroviral therapy failure caused by an interaction between carbamazepine and indinavir. CASE SUMMARY: A 48-year-old HIV-positive white man was treated with antiretroviral triple therapy, consisting of indinavir, zidovudine, and lamivudine. His HIV-RNA (viral load) became undetectable (
ISSN:1060-0280
1542-6270
DOI:10.1345/aph.19211