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Relative Safety and Efficacy of Finasteride for Treatment of Hirsutism
OBJECTIVE: To evaluate the relative safety and efficacy of finasteride for treatment of hirsutism related to hyperandrogenism in women. DATA SOURCES: Literature retrieval was accessed through MEDLINE (1966-March 2003) using the terms finasteride and hirsutism. Additional information was obtained fro...
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| Published in: | The Annals of pharmacotherapy 2004-06, Vol.38 (6), p.1070-1073 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c343t-53cca5b485bbf7d133835664034267ad972527c81186fe6277c9dd14361b00c93 |
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| cites | cdi_FETCH-LOGICAL-c343t-53cca5b485bbf7d133835664034267ad972527c81186fe6277c9dd14361b00c93 |
| container_end_page | 1073 |
| container_issue | 6 |
| container_start_page | 1070 |
| container_title | The Annals of pharmacotherapy |
| container_volume | 38 |
| creator | Townsend, Kara A Marlowe, Karen F |
| description | OBJECTIVE:
To evaluate the relative safety and efficacy of finasteride for treatment of hirsutism related to hyperandrogenism in women.
DATA SOURCES:
Literature retrieval was accessed through MEDLINE (1966-March 2003) using the terms finasteride and hirsutism. Additional information was obtained from the drug manufacturer.
DATA SYNTHESIS:
Finasteride has been evaluated for treatment of hirsutism in multiple observational and randomized trials. Finasteride lowered hirsutism scores by 30–60% in most trials, as well as decreasing average hair diameter. In comparative trials, finasteride demonstrated efficacy similar to that of other antiandrogens, with fewer adverse effects.
CONCLUSIONS:
Finasteride does reduce the overall hair diameter and number in androgen-sensitive areas. Reported adverse effects have been minimal. Concern over potential teratogenicity and lack of long-term safety information leave finasteride a secondary treatment option for hirsutism. |
| doi_str_mv | 10.1345/aph.1D461 |
| format | article |
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To evaluate the relative safety and efficacy of finasteride for treatment of hirsutism related to hyperandrogenism in women.
DATA SOURCES:
Literature retrieval was accessed through MEDLINE (1966-March 2003) using the terms finasteride and hirsutism. Additional information was obtained from the drug manufacturer.
DATA SYNTHESIS:
Finasteride has been evaluated for treatment of hirsutism in multiple observational and randomized trials. Finasteride lowered hirsutism scores by 30–60% in most trials, as well as decreasing average hair diameter. In comparative trials, finasteride demonstrated efficacy similar to that of other antiandrogens, with fewer adverse effects.
CONCLUSIONS:
Finasteride does reduce the overall hair diameter and number in androgen-sensitive areas. Reported adverse effects have been minimal. Concern over potential teratogenicity and lack of long-term safety information leave finasteride a secondary treatment option for hirsutism.</description><identifier>ISSN: 1060-0280</identifier><identifier>EISSN: 1542-6270</identifier><identifier>DOI: 10.1345/aph.1D461</identifier><identifier>PMID: 15100391</identifier><language>eng</language><publisher>Los Angeles, CA: Harvey Whitney Books</publisher><subject>5-alpha Reductase Inhibitors ; Enzyme Inhibitors - adverse effects ; Enzyme Inhibitors - therapeutic use ; Female ; Finasteride - adverse effects ; Finasteride - therapeutic use ; Hirsutism - drug therapy ; Humans ; Randomized Controlled Trials as Topic</subject><ispartof>The Annals of pharmacotherapy, 2004-06, Vol.38 (6), p.1070-1073</ispartof><rights>2004 SAGE Publications</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-53cca5b485bbf7d133835664034267ad972527c81186fe6277c9dd14361b00c93</citedby><cites>FETCH-LOGICAL-c343t-53cca5b485bbf7d133835664034267ad972527c81186fe6277c9dd14361b00c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15100391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Townsend, Kara A</creatorcontrib><creatorcontrib>Marlowe, Karen F</creatorcontrib><title>Relative Safety and Efficacy of Finasteride for Treatment of Hirsutism</title><title>The Annals of pharmacotherapy</title><addtitle>Ann Pharmacother</addtitle><description>OBJECTIVE:
To evaluate the relative safety and efficacy of finasteride for treatment of hirsutism related to hyperandrogenism in women.
DATA SOURCES:
Literature retrieval was accessed through MEDLINE (1966-March 2003) using the terms finasteride and hirsutism. Additional information was obtained from the drug manufacturer.
DATA SYNTHESIS:
Finasteride has been evaluated for treatment of hirsutism in multiple observational and randomized trials. Finasteride lowered hirsutism scores by 30–60% in most trials, as well as decreasing average hair diameter. In comparative trials, finasteride demonstrated efficacy similar to that of other antiandrogens, with fewer adverse effects.
CONCLUSIONS:
Finasteride does reduce the overall hair diameter and number in androgen-sensitive areas. Reported adverse effects have been minimal. Concern over potential teratogenicity and lack of long-term safety information leave finasteride a secondary treatment option for hirsutism.</description><subject>5-alpha Reductase Inhibitors</subject><subject>Enzyme Inhibitors - adverse effects</subject><subject>Enzyme Inhibitors - therapeutic use</subject><subject>Female</subject><subject>Finasteride - adverse effects</subject><subject>Finasteride - therapeutic use</subject><subject>Hirsutism - drug therapy</subject><subject>Humans</subject><subject>Randomized Controlled Trials as Topic</subject><issn>1060-0280</issn><issn>1542-6270</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNptkEFLw0AQhRdRbK0e_AOSk-AhOpPdbJKj1NYKBUHredlsdtstSVp2U0P_vVtb8OJpBuZ7j3mPkFuER6QsfZLb1SO-MI5nZIgpS2KeZHAeduAQQ5LDgFx5vwaAApPikgwwRQBa4JBMP3QtO_uto09pdLePZFtFE2OskmofbUw0ta30nXa20pHZuGjhtOwa3XaH48w6v-usb67JhZG11zenOSJf08liPIvn769v4-d5rCijXZxSpWRasjwtS5NVSGlOU84ZUJbwTFZFlqRJpnLEnBsdUmSqqCpklGMJoAo6Ig9HX-U23jttxNbZRrq9QBCHLkToQvx2Edi7I7vdlY2u_shT-ADcHwEvl1qsNzvXht__dTqBK7tc9dZp4RtZ18EXRd_3NBc8qDKgP0vTcfg</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>Townsend, Kara A</creator><creator>Marlowe, Karen F</creator><general>Harvey Whitney Books</general><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20040601</creationdate><title>Relative Safety and Efficacy of Finasteride for Treatment of Hirsutism</title><author>Townsend, Kara A ; Marlowe, Karen F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-53cca5b485bbf7d133835664034267ad972527c81186fe6277c9dd14361b00c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>5-alpha Reductase Inhibitors</topic><topic>Enzyme Inhibitors - adverse effects</topic><topic>Enzyme Inhibitors - therapeutic use</topic><topic>Female</topic><topic>Finasteride - adverse effects</topic><topic>Finasteride - therapeutic use</topic><topic>Hirsutism - drug therapy</topic><topic>Humans</topic><topic>Randomized Controlled Trials as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Townsend, Kara A</creatorcontrib><creatorcontrib>Marlowe, Karen F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The Annals of pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Townsend, Kara A</au><au>Marlowe, Karen F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relative Safety and Efficacy of Finasteride for Treatment of Hirsutism</atitle><jtitle>The Annals of pharmacotherapy</jtitle><addtitle>Ann Pharmacother</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>38</volume><issue>6</issue><spage>1070</spage><epage>1073</epage><pages>1070-1073</pages><issn>1060-0280</issn><eissn>1542-6270</eissn><abstract>OBJECTIVE:
To evaluate the relative safety and efficacy of finasteride for treatment of hirsutism related to hyperandrogenism in women.
DATA SOURCES:
Literature retrieval was accessed through MEDLINE (1966-March 2003) using the terms finasteride and hirsutism. Additional information was obtained from the drug manufacturer.
DATA SYNTHESIS:
Finasteride has been evaluated for treatment of hirsutism in multiple observational and randomized trials. Finasteride lowered hirsutism scores by 30–60% in most trials, as well as decreasing average hair diameter. In comparative trials, finasteride demonstrated efficacy similar to that of other antiandrogens, with fewer adverse effects.
CONCLUSIONS:
Finasteride does reduce the overall hair diameter and number in androgen-sensitive areas. Reported adverse effects have been minimal. Concern over potential teratogenicity and lack of long-term safety information leave finasteride a secondary treatment option for hirsutism.</abstract><cop>Los Angeles, CA</cop><pub>Harvey Whitney Books</pub><pmid>15100391</pmid><doi>10.1345/aph.1D461</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1060-0280 |
| ispartof | The Annals of pharmacotherapy, 2004-06, Vol.38 (6), p.1070-1073 |
| issn | 1060-0280 1542-6270 |
| language | eng |
| recordid | cdi_crossref_primary_10_1345_aph_1D461 |
| source | SAGE:Jisc Collections:SAGE Journals Read and Publish 2023-2024:2025 extension (reading list) |
| subjects | 5-alpha Reductase Inhibitors Enzyme Inhibitors - adverse effects Enzyme Inhibitors - therapeutic use Female Finasteride - adverse effects Finasteride - therapeutic use Hirsutism - drug therapy Humans Randomized Controlled Trials as Topic |
| title | Relative Safety and Efficacy of Finasteride for Treatment of Hirsutism |
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