Determination of Sotalol in Tablets and Serum by CZE

A validated capillary zone electrophoretic method for analysis of sotalol is described. Analysis was performed in a fused-silica capillary with 20 mM phosphate buffer (pH 4.20) containing 10% (v/v) acetonitrile as background electrolyte. The applied potential was +20 kV, the injection time 0.08 min,...

Full description

Saved in:
Bibliographic Details
Published in:Chromatographia 2007-09, Vol.66 (S1), p.159-163
Main Authors: Dogrukol-Ak, D, Dal, A. G, Tunçel, M
Format: Article
Language:English
Subjects:
capillary zone electrophoresis
Sotalol in tablets and serum
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A validated capillary zone electrophoretic method for analysis of sotalol is described. Analysis was performed in a fused-silica capillary with 20 mM phosphate buffer (pH 4.20) containing 10% (v/v) acetonitrile as background electrolyte. The applied potential was +20 kV, the injection time 0.08 min, signal detection was at 200 nm, and 3,4-dihydoxybenzylamine was used as internal standard. The method was validated over the concentration range 1.98 x 10-⁵ to 9.90 x 10-⁵ M; repeatability was good and there was no interference. Highly satisfactory results were obtained from analysis of tablets and serum, indicating the method is specific, accurate, and precise, and suitable for routine analysis of sotalol in pharmaceutical tablets and in pharmacokinetic studies.
ISSN:0009-5893
1612-1112
DOI:10.1365/s10337-007-0312-9