GC-MS Determination of Sucralose in Splenda

Sucralose (1,6-dichloro-1,6-dideoxy-β-d-fructofuranosyl-4-chloro-4-deoxy-α-d-galactopyranoside) is a high-intensity non-nutritive sweetener derived from sucrose. Determination of sucralose in food is important to ensure consistent product quality. The authors have developed a new method for determin...

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Bibliographic Details
Published in:Chromatographia 2007-12, Vol.66 (11-12), p.935-939
Main Authors: Qiu, Wenlong, Wang, Zhongfu, Nie, Wanli, Guo, Yuna, Huang, Linjuan
Format: Article
Language:English
Subjects:
Biological and medical sciences
Food additives
Food industries
Fragmentation patterns
Fundamental and applied biological sciences. Psychology
gas chromatography
General aspects
mass spectrometry
quantitative analysis
Splenda
sucralose
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Summary:Sucralose (1,6-dichloro-1,6-dideoxy-β-d-fructofuranosyl-4-chloro-4-deoxy-α-d-galactopyranoside) is a high-intensity non-nutritive sweetener derived from sucrose. Determination of sucralose in food is important to ensure consistent product quality. The authors have developed a new method for determination of sucralose. The sucralose was converted into its trimethylsilyl (TMS) ether and qualitative and quantitative analysis were achieved by GC-MS and GC-FID, respectively, using myo-inositol ester as the internal standard. A good linear relationship between response and amount of sucralose TMS ether was obtained in the range 0.005-0.06 mg mL-¹ (r = 0.9994). The detection limit was 0.25 ng.
ISSN:0009-5893
1612-1112
DOI:10.1365/s10337-007-0422-4