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Imidazole-2-carboxaldehyde Chitosan Thiosemicarbazones and their Copper(II) Complexes: Synthesis, Characterization and Antitumorigenic Activity against Madin-Darby Canine Kidney Cell Line
Chitosan oligosaccharide and high molecular weight crab shell chitosan were functionalized as imidazole-2-carboxaldehyde chitosan thiosemicarbazones and their copper(II) complexes were synthesized. The synthesized compounds were characterized by FT-IR, 13C NMR, EPR spectroscopy, powder X-ray diffrac...
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Published in: | Asian journal of chemistry 2021-05, Vol.33 (5), p.969-976 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Chitosan oligosaccharide and high molecular weight crab shell chitosan were functionalized as
imidazole-2-carboxaldehyde chitosan thiosemicarbazones and their copper(II) complexes were
synthesized. The synthesized compounds were characterized by FT-IR, 13C NMR, EPR spectroscopy,
powder X-ray diffraction (PXRD) analysis, elemental analysis and magnetic susceptibility
measurements. The low molecular weight chitosan thiosemicarbazones showed higher in vitro inhibitory
activity as studied by MTT assay against the tumorigenic epithelial Madin-Darby Canine Kidney
(MDCK) cell line than the corresponding high molecular weight chitosan derivative. The antitumorigenic
enhancement upon the complex formation was revealed by the better inhibitory activity of copper(II)
chitosan thiosemicarbazone chelates. |
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ISSN: | 0970-7077 0975-427X |
DOI: | 10.14233/ajchem.2021.23078 |