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Antithrombotic, Antihemolytic Activities and Protein Conjugation Properties of Silver Nanoparticles Synthesized from Turbinaria ornata
Green synthesis of silver nanoparticles synthesized from Turbinaria ornata weed extract was carried out. Because these seaweeds are largely unexplored and contain botanical molecules that promote bimolecular reduction. In this study, silver nanoparticles (AgNPs) cause a rise in the accumulation of c...
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Published in: | Asian journal of chemistry 2021-08, Vol.33 (8), p.1736-1742 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Green synthesis of silver nanoparticles synthesized from Turbinaria ornata weed extract was carried
out. Because these seaweeds are largely unexplored and contain botanical molecules that promote
bimolecular reduction. In this study, silver nanoparticles (AgNPs) cause a rise in the accumulation of
clotting factors, platelets and procoagulant activity, both of which lead to thrombotic and hemolytic
diseases. The silver nanoparticles were initially characterized using spectroscopic analysis to validate
the biomolecules of Turbinaria ornata involved in nanoparticle reduction. A detailed study on the
effectiveness of silver nanoparticles on antithrombolytic activity in adult blood samples confirms the
interaction of nanoparticles with platelets and blood vessels, which is significant in the production of
thrombosis and cardiovascular diseases. The antihemolytic activity was tested to assess the percentage
of blood clot lysis in order to confirm the ability to scavenge hydrogen peroxide in a concentration
dependent manner. The protein conjugation and binding activities of major, secondary, and tertiary
structures were also investigated in silico. Thus, Turbinaria ornata seaweeds with reduced silver
nanoparticles demonstrated increased antithrombotic and antihemolytic activities, suggested that they
could be used as novel therapeutics for cardiovascular diseases. |
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ISSN: | 0970-7077 0975-427X |
DOI: | 10.14233/ajchem.2021.23237 |