Preliminary Screening for Potential Compounds in Inhibiting Enzyme Tyrosinase from 11 Herbal Extracts

Considering the emerging trends of using natural ingredients in the cosmetic industry, this study was undertaken to confirm the efficiency of some traditional skin-whitening plants in Vietnam. In this study, 11 popular Vietnamese herbal extracts were investigated in suppressing mushroom tyrosinase a...

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Bibliographic Details
Published in:Asian journal of chemistry 2022, Vol.34 (12), p.3257-3262
Main Authors: Le, Xuan-Tien, Le, Khai-Vinh, Tran-Thi, Tuyet-Anh, Huynh, Kieu-Trang
Format: Article
Language:English
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Summary:Considering the emerging trends of using natural ingredients in the cosmetic industry, this study was undertaken to confirm the efficiency of some traditional skin-whitening plants in Vietnam. In this study, 11 popular Vietnamese herbal extracts were investigated in suppressing mushroom tyrosinase activity. The most potent material was then analyzed for phytochemicals profiles and the extraction process was optimized by single-factor experiments. It was found that Morus alba leaves extract using ethanol had superior mushroom tyrosinase inhibitory activity. The extract under optimal conditions (extract 2 cycles with ethanol 70%, temperature: 50 ºC, time: 40 min and solid/liquid ratio = 1:10) contained polyphenols, flavonoids, saponins and tannins and its biological properties included: antityrosinase IC50 = 99.4 μg/mL, antioxidation IC50 (DPPH assay) = 85.7 μg/mL and total phenolic content TPC (GAE) = 128.6 mg/g extract.
ISSN:0970-7077
0975-427X
DOI:10.14233/ajchem.2022.23998