Synthesis, Characterization, Molecular Docking Studies and Biological Evaluation of Thiazole Schiff Base Analogs

In this work, potentially safe few Schiff base compounds containing a thiazole moiety were synthesized and characterized. Three thiazole derivatives (2a-c) were successfully synthesized through a two-step reaction involving substituted benzaldehyde, thiosemicarbazide and 1,3-dichloroacetone. The elu...

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Bibliographic Details
Published in:Asian journal of chemistry 2024-03, Vol.36 (3), p.649-654
Main Authors: Rahman, Muhammad Zoadur, Islam, Md. Din, Haque, Md. Aminul, Rahman, Mohammad Mostafizur, Hossain, Emdad, Sutradhar, Ranajit Kumar
Format: Article
Language:English
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Summary:In this work, potentially safe few Schiff base compounds containing a thiazole moiety were synthesized and characterized. Three thiazole derivatives (2a-c) were successfully synthesized through a two-step reaction involving substituted benzaldehyde, thiosemicarbazide and 1,3-dichloroacetone. The elucidation of the synthesized compounds was accomplished by using spectral studies. Antimicrobial activities demonstrated that some compounds exhibited moderate effectiveness against microbes, compared to the standard antibiotic’s ceftriaxone and amphotericin B, using the disc diffusion technique. In the DPPH free radical scavenging assay, all compounds displayed promising antioxidant effectiveness. Moreover, the molecular docking studies showed that thiazole Schiff base analogs effectively bind to potential receptor binding sites.
ISSN:0970-7077
0975-427X
DOI:10.14233/ajchem.2024.31077