Upadacitinib-Induced Hepatitis B Reactivation Leading to Liver Transplant

Hepatitis B virus (HBV) reactivation can occur with the use of immunosuppressive therapy used to treat autoimmune conditions, such as rheumatoid arthritis. Janus kinase inhibitors, such as upadacitinib, have been approved for the treatment of rheumatoid arthritis. This is the first case report of a...

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Bibliographic Details
Published in:ACG case reports journal 2024-04, Vol.11 (4), p.e01327
Main Authors: Khan, Sarosh Ahmed, Zahid, Rida, Amir, Muhammad
Format: Article
Language:English
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Summary:Hepatitis B virus (HBV) reactivation can occur with the use of immunosuppressive therapy used to treat autoimmune conditions, such as rheumatoid arthritis. Janus kinase inhibitors, such as upadacitinib, have been approved for the treatment of rheumatoid arthritis. This is the first case report of a patient who used upadacitinib without antiviral prophylaxis against HBV and developed HBV reactivation, leading to fulminant hepatic failure necessitating emergent liver transplantation.
ISSN:2326-3253
2326-3253
DOI:10.14309/crj.0000000000001327