Integrated Testing Strategies (ITS) for safety assessment

Integrated testing strategies (ITS), as opposed to single definitive tests or fixed batteries of tests, are expected to efficiently combine different information sources in a quantifiable fashion to satisfy an information need, in this case for regulatory safety assessments. With increasing awarenes...

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Bibliographic Details
Published in:ALTEX, alternatives to animal experimentation alternatives to animal experimentation, 2015, Vol.32 (1), p.25-40
Main Authors: Rovida, Costanza, Alépée, Nathalie, Api, Anne M, Basketter, David A, Bois, Frédéric Y, Caloni, Francesca, Corsini, Emanuela, Daneshian, Mardas, Eskes, Chantra, Ezendam, Janine, Fuchs, Horst, Hayden, Patrick, Hegele-Hartung, Christa, Hoffmann, Sebastian, Hubesch, Bruno, Jacobs, Miriam N, Jaworska, Joanna, Kleensang, André, Kleinstreuer, Nicole, Lalko, Jon, Landsiedel, Robert, Lebreux, Frédéric, Luechtefeld, Thomas, Locatelli, Monica, Mehling, Annette, Natsch, Andreas, Pitchford, Jonathan W, Prater, Donald, Prieto, Pilar, Schepky, Andreas, Schüürmann, Gerrit, Smirnova, Lena, Toole, Colleen, van Vliet, Erwin, Weisensee, Dirk, Hartung, Thomas
Format: Article
Language:English
Subjects:
Animal Testing Alternatives
Animals
Europe
Humans
Risk Assessment
Toxicity Tests - methods
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Summary:Integrated testing strategies (ITS), as opposed to single definitive tests or fixed batteries of tests, are expected to efficiently combine different information sources in a quantifiable fashion to satisfy an information need, in this case for regulatory safety assessments. With increasing awareness of the limitations of each individual tool and the development of highly targeted tests and predictions, the need for combining pieces of evidence increases. The discussions that took place during this workshop, which brought together a group of experts coming from different related areas, illustrate the current state of the art of ITS, as well as promising developments and identifiable challenges. The case of skin sensitization was taken as an example to understand how possible ITS can be constructed, optimized and validated. This will require embracing and developing new concepts such as adverse outcome pathways (AOP), advanced statistical learning algorithms and machine learning, mechanistic validation and "Good ITS Practices".
ISSN:1868-596X
1868-596X
DOI:10.14573/altex.1411011