Biochemical evaluation of hydroxyurea derivative schiff bases in liver of rats

In this study, it was aimed to examine the antioxidant and antihepatotoxic effects of hydroxyurea derivative Schiff bases on serum biochemical parameters (AST, ALT, LDH, urea, creatinine and total bilirubin) and antioxidant parameters (SOD, CAT, GPx, MDA). In this study, a total of 49 adult male Wis...

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Published in:Cellular and Molecular Biology 2017-11, Vol.63 (11), p.5-10
Main Authors: Parlak, Akif Evren, Karagozoglu, Yusuf, Alayunt, Naci O., Turkoglu, Semra, Yildirim, Isil, Karatepe, Mustafa, Koparir, Metin
Format: Article
Language:English
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Summary:In this study, it was aimed to examine the antioxidant and antihepatotoxic effects of hydroxyurea derivative Schiff bases on serum biochemical parameters (AST, ALT, LDH, urea, creatinine and total bilirubin) and antioxidant parameters (SOD, CAT, GPx, MDA). In this study, a total of 49 adult male Wistar rats was examined and they were divided into 7 equal groups. DMSO, which is diluted only with corn oil, was administered to control group. 25 mg / kg ligand, 25 mg / kg Schiff base - manganese, 25 mg / kg Schiff base-copper, 25 mg / kg Schiff base - zinc, 25 mg / kg Schiff base - nickel, 25 mg / kg Schiff base - cobalt complexes were administered to rats of experimental group subcutaneously for 15 days with three-day intervals throughout the test process. All specimens were killed by decapitation and their livers were extracted. According to the results obtained, ALT level was observed to be higher (P
ISSN:0145-5680
1165-158X
DOI:10.14715/cmb/2017.63.11.2