Relationship between MCP1 (-2518A>G) gene variants and ovarian cancer in Turkish population

The monocyte chemoattractant protein-1 (MCP-1) gene polymorphism(-2518A>G)  in the regulatory region of the MCP-1 protein has been reported to be associated with cancer risk. In this study we aimed to investigate the relationship of MCP-1 (-2518A>G) gene polymorphism and ovarian cancer. MCP-1...

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Bibliographic Details
Published in:Cellular and Molecular Biology 2017-08, Vol.63 (8), p.100-103
Main Authors: Attar, R., Yilmaz, S. G., í‡akmakoğlu, B., Duman, S., Yildirim, G., Görmüş, U., ć°sbir, T.
Format: Article
Language:English
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Summary:The monocyte chemoattractant protein-1 (MCP-1) gene polymorphism(-2518A>G)  in the regulatory region of the MCP-1 protein has been reported to be associated with cancer risk. In this study we aimed to investigate the relationship of MCP-1 (-2518A>G) gene polymorphism and ovarian cancer. MCP-1 genotyping was performed using polymerase chain reaction from blood samples ofovarian cancer patient (n=56) and a control groups (n=52).There was a significant difference in MCP1 (-2518A>G) genotypes between the patient and control groups (p=0.049; x2=6.042). AA carriers were significantly higher in the control group (p=0.014) whereas AG genotype and G allele carriers were significantly higher in the ovarian cancer group (p=0.029, p=0.014, respectively). This study suggests that MCP-1 (-2518A>G) AG genotype and G allele could be considered as risk factor for susceptibility to ovarian cancer.
ISSN:0145-5680
1165-158X
DOI:10.14715/cmb/2017.63.8.21