The COX2 genetic variants in oral squamous cell carcinoma in Turkish population

Oral squamous cell carcinoma (OSCC) is a common type of cancer that genetic and environmental factors also lifestyle habits, infections play important roles in the pathogenesis of disease. Cyclooxygenase 2 (COX2) is the inducible isoform of enzyme which convert arachidonic acid to prostaglandins. It...

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Bibliographic Details
Published in:Cellular and Molecular Biology 2018-11, Vol.64 (14), p.96-100
Main Authors: Cacina, Canan, Kaşarci, Göksu, Bektaş, Kivanç, Unur, Meral, Cakmakoglu, Bedia
Format: Article
Language:English
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Summary:Oral squamous cell carcinoma (OSCC) is a common type of cancer that genetic and environmental factors also lifestyle habits, infections play important roles in the pathogenesis of disease. Cyclooxygenase 2 (COX2) is the inducible isoform of enzyme which convert arachidonic acid to prostaglandins. It was known that alterations in COX2 gene functions contribute to the inflammation process thus induce cancer progression, including cell proliferation, apoptosis, adhesion, invasion and metastasis. A total of 114 cases 165 healthy individuals were included in present study. We aimed to evaluate possible association between the COX2; -765, -1195 polymorphisms and the risk of OSCC. The genotypes were determined by using polymerase chain reaction restriction fragment length polymorphism techniques. In our study group the carriers of COX2 -765 C allele were statistically higher in patients compared with controls and individuals who had CC genotype had a 3,4 fold high risk for OSCC (p
ISSN:0145-5680
1165-158X
DOI:10.14715/cmb/2018.64.14.16