Childhood Thyroid Cancer: Comparison of Japan and Belarus

The high incidence of childhood thyroid cancer in Belarus is suspected to be due to radiation exposure after the Chernobyl reactor accident. To clarify the clinical and histological characteristics of childhood thyroid cancer in Belarus, we therefore compared these patients to a radiation non-expose...

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Published in:ENDOCRINE JOURNAL 1998, Vol.45(2), pp.203-209
Main Authors: SHIRAHIGE, YUTAKA, ITO, MASAHIRO, ASHIZAWA, KIYOTO, MOTOMURA, TOMOKO, YOKOYAMA, NAOKATA, NAMBA, HIROYUKI, FUKATA, SHUJI, YOKOZAWA, TAMOTSU, ISHIKAWA, NAOFUMI, MIMURA, TAKASHI, YAMASHITA, SHUNICHI, SEKINE, ICHIRO, KUMA, KANJI, ITO, KUNIHIKO, NAGATAKI, SHIGENOBU
Format: Article
Language:English
Subjects:
Adenocarcinoma, Follicular - epidemiology
Adolescent
Age Factors
Carcinoma, Papillary - epidemiology
Chernobyl
Child
Child, Preschool
Children
Female
Follow-Up Studies
Humans
Japan
Japan - epidemiology
Male
Neoplasm Metastasis
Neoplasm Staging
Power Plants
Radiation
Radioactive Hazard Release
Republic of Belarus - epidemiology
Thyroid neoplasms
Thyroid Neoplasms - epidemiology
Thyroid Neoplasms - pathology
Thyroid Neoplasms - surgery
Thyroidectomy
Ukraine
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Summary:The high incidence of childhood thyroid cancer in Belarus is suspected to be due to radiation exposure after the Chernobyl reactor accident. To clarify the clinical and histological characteristics of childhood thyroid cancer in Belarus, we therefore compared these patients to a radiation non-exposed control series in Japan. In Belarus, 26 thyroid cancers in subjects aged 15 or younger were diagnosed among 25, 000 screened between 1991 and 1995 by Chernobyl-Sasakawa Health and Medical Cooperation Project. The clinical and morphologic features of these 26 cases were compared to 37 childhood thyroid cancers in Japan diagnosed between 1962 and 1995. The age distribution at operation in Belarus showed a peak at 10 years old, with a subsequent fall in numbers. In contrast, the age distribution at operation in Japan showed a smooth increase between the ages of 8 and 14. The mean tumor diameter was smaller in Belarus than that in Japan (1.4±0.7 vs. 4.1±1.7cm, P
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.45.203