Association of Takayasu's Disease and Autoimmune Gestational Diabetes Mellitus

• Published in: ENDOCRINE JOURNAL 2000, Vol.47(2), pp.203-204
• Main Authors: MAURICIO, Didac, CORCOY, Rosa, MORALES, Josefa, VIDALLER, A., ADELANTADO, Joan M., GARCIA-PATTERSON, Apolonia, CALLS, Oscar de La, LEIVA, Alberto de
• Format: Article
• Language: English
• Subjects: Adult; Autoantibodies - blood; Autoimmune Diseases - complications; Diabetes, Gestational - complications; Diabetes, Gestational - immunology; Female; Histocompatibility Testing; Humans; Pregnancy; Pregnancy Complications; Takayasu Arteritis - complications; Takayasu Arteritis - immunology
• ISSN: 0918-8959; 1348-4540
• DOI: 10.1507/endocrj.47.203

Takayasu's arteritis (TA) is an immune-mediated disease involving large arteries [1] , where associations with other autoimmune conditions including Type 1 diabetes mellitus (DM) have been described [1, 2]. We report a patient with TA, gestational diabetes mellitus (GDM) and positive islet cell (ICA), antithyroid and gastric parietal cell antibodies. A 29-year-old non-obese pregnant woman was seen because of GDM. Seven years before she was diagnosed as TA involving left carotid, superior mesenteric and both renal arteries. Constitutional symptoms responded to prednisolone that was tapered to 14. 5mg/48 h. At 24 weeks of her first pregnancy, a 100 g oral glucose tolerance test (OGTT) was diagnostic of GDM (fasting 72 mg/dL, 1h 197 mg/dL, 2 h 176 mg/dL, 3 h 123 mg/dL). Autoantibodies against islet cell (5 JDF units), gastric parietal cell (1/40) and thyroid microsomes (1/40) were positive. Isocaloric diet was initiated and from 33 weeks onwards insulin therapy was required to maintain euglycemia. A rupture of membranes supervened at 35 weeks and a healthy male fetus was delivered by cesarean section. Four months after delivery, ICA were positive (5 JDF units) and a 75 g OGTT was normal.