An Assessment of Bone Mineral Density in Patients with Addison's Disease and Isolated ACTH Deficiency Treated with Glucocorticoid

Glucocorticoid replacement therapy needs to be tailored to individual patient's requirements in order to avoid risk of over or under medication. We measured bone mineral density (BMD) of lumbar spine using dual X-ray absorptiometory in 10 patients with Addison's disease and 5 patients with...

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Bibliographic Details
Published in:Endocrine Journal 2004, Vol.51(3), pp.355-360
Main Authors: CHIKADA, Naoko, IMAKI, Toshihiro, HOTTA, Mari, SATO, Kanji, TAKANO, Kazue
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Addison Disease - drug therapy
Addison Disease - physiopathology
Addison's disease
Adrenocorticotropic Hormone - blood
Adrenocorticotropic Hormone - deficiency
Adult
Aged
Aged, 80 and over
Bone Density
Bone mineral density
Dose-Response Relationship, Drug
Dual X-ray absorptiometry
Eosinophils
Female
Glucocorticoid
Glucocorticoids - adverse effects
Glucocorticoids - therapeutic use
Humans
Hydrocortisone - administration & dosage
Hydrocortisone - adverse effects
Isolated ACTH deficiency
Leukocyte Count
Male
Middle Aged
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Summary:Glucocorticoid replacement therapy needs to be tailored to individual patient's requirements in order to avoid risk of over or under medication. We measured bone mineral density (BMD) of lumbar spine using dual X-ray absorptiometory in 10 patients with Addison's disease and 5 patients with isolated ACTH deficiency receiving glucocorticoid replacement therapy. We also examined the effect of glucocorticoid replacement on BMD. Decreased %BMD (less than 80% of age-matched controls) was found in 2 female patients who had received hydrocortisone at a dose of 14.8 and 15.4 mg/m2/day. In contrast, no patient receiving a hydrocortisone dose of less than 12.4 mg/m 2/day had decreased %BMD. There was no correlation between %BMD and hydrocortisone dose (mg/m2), duration of therapy, or cumulative hydrocortisone dose when treated with appropriate dose of hydrocortisone (
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.51.355