Association between Serum Ferritin and Circulating Oxidized Low-density Lipoprotein Levels in Patients with Type 2 Diabetes

The oxidative modification of low-density lipoproteins (LDL) plays a central role in the initiation and acceleration of atherosclerosis. Iron plays a part in the formation of highly toxic free radicals such as hydroxide and superoxide anions, which can induce lipid peroxidation. We investigated whet...

Full description

Saved in:
Bibliographic Details
Published in:Endocrine Journal 2006, Vol.53(5), pp.665-670
Main Authors: IKEDA, Yukio, SUEHIRO, Tadashi, YAMANAKA, Shigeo, KUMON, Yoshitaka, TAKATA, Hiroshi, INADA, Shojiro, OGAMI, Naoko, OSAKI, Fumiaki, INOUE, Mari, ARII, Kaoru, HASHIMOTO, Kozo
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
Body Mass Index
Cholesterol, LDL - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - epidemiology
Female
Ferritin
Ferritins - blood
Humans
Iron
Lipid Peroxidation
Lipoproteins, LDL - blood
Male
Middle Aged
Oxidized LDL
Regression Analysis
Sex Characteristics
Type 2 diabetes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The oxidative modification of low-density lipoproteins (LDL) plays a central role in the initiation and acceleration of atherosclerosis. Iron plays a part in the formation of highly toxic free radicals such as hydroxide and superoxide anions, which can induce lipid peroxidation. We investigated whether serum iron status was associated with circulating oxidized LDL (oxLDL) levels in type 2 diabetic patients, in whom oxidative stress and susceptibility to lipid oxidation were supposedly increased. Serum ferritin levels were significantly correlated with plasma oxLDL concentrations in both male and female patients (p
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.K06-010