Ensuring defined porosity and pore size using ammonium hydrogen carbonate as porosification agent for calcium phosphate scaffolds

Up to now, it has been very challenging to manufacture a degradable bone replacement material having a specific pore size as well as a specific percentage of porosity which can be set independently of one another. We hypothesize that this is possible by using ammonium hydrogen carbonate (NH HCO ) as...

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Bibliographic Details
Published in:Bionanomaterials (Berlin, Germany) Germany), 2013, Vol.14 (1), p.101-108
Main Authors: Lindner, Markus, Schickle, Karolina, Bergmann, Christian, Fischer, Horst
Format: Article
Language:English
Subjects:
ammonium hydrogen carbonate
bioceramics
calcium phosphate
pore size
porosity
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Summary:Up to now, it has been very challenging to manufacture a degradable bone replacement material having a specific pore size as well as a specific percentage of porosity which can be set independently of one another. We hypothesize that this is possible by using ammonium hydrogen carbonate (NH HCO ) as porosification agent in varying particle size fractions and varying percentages in combination with β-tricalcium phosphate (β-TCP) material to manufacture tailored porous β-TCP scaffolds. In our study the pore sizes of the sintered material were comparable to the selected particle size fraction of the porosification agent. Porosities ranging between 71 and 78 vol.% were achieved. It was possible to control the volume percentage of porosity by using different weight ratios of NH HCO and β-TCP. It can be concluded that ammonium hydrogen carbonate is an excellent porosification agent to design β-tricalcium phosphate scaffolds. This agent allows the independent setting of a specific pore size range as well as a specific volume percentage of porosity.
ISSN:2193-0651
2193-066X
DOI:10.1515/bnm-2012-0005