Solid-Phase Extraction, Identification, and Quantitation of 11-Nor-Delta-9-Tetrahydrocannabinol-9-Carboxylic Acid

A procedure has been developed to extract and recover minute amounts of delta-9-carboxytetrahydrocannabinol (THC-COOH) from urine. A new non-isotopic internal standard is introduced to permit a chromatographic assay of the metabolite. The method affords a 91% recovery of 20 ng/mL of the THC-COOH aci...

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Bibliographic Details
Published in:Journal of forensic sciences 1990-07, Vol.35 (4), p.792-796
Main Authors: Nakamura, GR, Meeks, RD, Stall, WJ
Format: Article
Language:English
Subjects:
Chromatography
Chromatography, Gas
Dronabinol - analogs & derivatives
Dronabinol - isolation & purification
Dronabinol - urine
Humans
Hydrogen-Ion Concentration
Hydrolysis
Marijuana
Mass Spectrometry
Meclofenamic Acid
Pharmacology
Reference Standards
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Summary:A procedure has been developed to extract and recover minute amounts of delta-9-carboxytetrahydrocannabinol (THC-COOH) from urine. A new non-isotopic internal standard is introduced to permit a chromatographic assay of the metabolite. The method affords a 91% recovery of 20 ng/mL of the THC-COOH acid from spiked urine with the assurance of a 3.8% coefficient of variation.
ISSN:0022-1198
1556-4029
DOI:10.1520/JFS12891J