STUDY OF THE IMMUNE DISORDERS IN NONSPECIFIC CHRONIC INFLAMMATORY DISEASES OF THE GENITAL ORGANS

• Published in: Fiziolohichnyĭ zhurnal 2022-06, Vol.68 (3), p.68-77
• Main Authors: Davydenko, К.І., Maltsev, D.V., Batman, Yu.A., Natrus, L.V.
• Format: Article
• Language: English
• ISSN: 2522-9028; 2522-9036
• DOI: 10.15407/fz68.03.068

To study immune disorders: immunograms of 50 adult women and 41 girls with recurrent non-specific genital inflammations, were performed in order to characterize the immunodeficiency in general and justify the treatment correction. The following gynecological examination procedures were performed: bacterioscopic, bacteriological, cytological and PCR tests, which didn’t reveal the specific infections. The control group was represented by 14 women and 14 girls of the same age, without appropriate complaints, healthy on gynecological examination. The patients with recurrent non-specific genital inflammations with the NKT-lymphocytes cytotoxic cells deficiency made up 65%, those with the immunoglobulin E (IgE) deficiency – 56%, the group with combined deficiency of both IgE and Natural Killer T-cell (NKT) – 33%. The IgE molecule content in morbid girls was almost twice less than that of the healthy ones, in adult women the IgE deficiency was 2.5 times less. The decrease in the NKT-lymphocytes in the group of girls was 4.9 times less compared to the control, and in healthy women, the decrease made up 1.9 times. The detected increase of small circulating complexes in blood plasma, which was observed in 88% of the patients, may be explained by the manifestations of the immune response to chronic infection in the genitals. The general immunoassay of patients with the non-specific genital inflammations showed the following immune disorder structure: the adaptive immunity humoral component disorder was in almost 70% of cases, the inborn immunity cellular component was in almost 60% of cases, the adaptive immunity cellular component was in 28% of cases, complement system disorders were in 26% of cases, and phagocytosis disorders were in 14% of cases. These immune disorders may be regarded as the basis of pharmacological correction aimed at covering for the immunodeficiency and intensification of the affected mucosa immune resistance.