PEDIATRIC HAZARDS OF DRUGS IN SOLUTIONS CONVENIENT FOR ADMINISTRATION TO ADULTS

Studies on the clinical pharmacology of drugs in newborn infants have uncovered a problem of overdosage which may be more common than generally appreciated. Several medicaments are available only in a limited number of highly concentrated formulations. The requirements of premature and full-term new...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1964-06, Vol.33 (6), p.999-999
Main Authors: AXLINE, S C, SIMON, H J
Format: Article
Language:English
Subjects:
Drug Therapy
Infant, Newborn
Kanamycin
Pharmaceutical Preparations
Solutions
Toxicology
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Summary:Studies on the clinical pharmacology of drugs in newborn infants have uncovered a problem of overdosage which may be more common than generally appreciated. Several medicaments are available only in a limited number of highly concentrated formulations. The requirements of premature and full-term newborn infants for very small total dosages necessitate very careful measurements of minute quantities of drug, and overdosage can readily occur. Specifically, Kanamycin is available in only two formulations for injection containing respectively 250 and 333 mg/ml. The dosage of this agent for newborn infants is approximately 8 mg/Kg of body weight 12 hourly.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.33.6.999