Hypertensive encephalopathy and desoxycorticosterone

Doctor Monteleone reports a patient with congenital adrenal hyperplasia who had permanent severe neurologic sequellae following DOC-induced hypertensive encephalopathy. Since the preparation of our previous manuscript, we have seen three additional children who have suffered from mineralocorticoid-i...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1969-02, Vol.43 (2), p.302-303
Main Authors: Marks, J F, Fink, C W
Format: Article
Language:English
Subjects:
Adrenocortical Hyperfunction - drug therapy
Brain Diseases - chemically induced
Desoxycorticosterone - administration & dosage
Desoxycorticosterone - adverse effects
Humans
Hypertension - chemically induced
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Summary:Doctor Monteleone reports a patient with congenital adrenal hyperplasia who had permanent severe neurologic sequellae following DOC-induced hypertensive encephalopathy. Since the preparation of our previous manuscript, we have seen three additional children who have suffered from mineralocorticoid-induced hypertension following the implantation of DOC pellets. Our experience would indicate that this complication of mineralocorticoid therapy is much more common than previously recognized. The administration of some long-acting form of salt-retaining hormone is necessary in the infant with the salt-losing form of adrenal hyper plasia.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.43.2.302a