Postural hypotension from imipramine

It was of interest to read that postural hypotension occurred in a patient in a "therapeutic dose" of imipramine.1 This, however, is common in patients on any of the tricyclic antidepressants (amitriptyline, nontriptyline, and so forth) as these drugs decrease the cardiovascular reflexes,...

Full description

Saved in:
Bibliographic Details
Published in:Pediatrics (Evanston) 1971-08, Vol.48 (2), p.331-332
Main Authors: Slovis, T L, Ott, J E
Format: Article
Language:English
Subjects:
Antidotes
Child
Female
Humans
Hypotension - chemically induced
Hypotension - drug therapy
Imipramine - administration & dosage
Imipramine - poisoning
Physostigmine - therapeutic use
Posture
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It was of interest to read that postural hypotension occurred in a patient in a "therapeutic dose" of imipramine.1 This, however, is common in patients on any of the tricyclic antidepressants (amitriptyline, nontriptyline, and so forth) as these drugs decrease the cardiovascular reflexes, such as carotid reflex, Bezold-janisch reflex, and postural reflexes.2,3 I take issue with the statement that the patient was on "therapeutic dosages of this drug," as she exhibited many of the toxic manifestations of this class of compounds.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.48.2.331