The effect of dilute corrosives on the esophagus

Cats were used in this study to demonstrate the effect of dilute corrosive drain cleaners upon the esophagus. Sulfuric acid, potassium hydroxide, and sodium hydroxide in less than 10% strength all produced gross and microscopic evidence of severe damage after 30-second exposure. We suggest that pres...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1974-02, Vol.53 (2), p.226-232
Main Authors: Ashcraft, K W, Padula, R T
Format: Article
Language:English
Subjects:
Animals
Burns, Chemical - pathology
Cats
Caustics - administration & dosage
Caustics - adverse effects
Esophageal Diseases - chemically induced
Esophageal Diseases - pathology
Esophagus - drug effects
Esophagus - pathology
Hydroxides - administration & dosage
Hydroxides - adverse effects
Mucous Membrane - drug effects
Necrosis
Potassium
Sodium
Solutions
Spasm - chemically induced
Sulfuric Acids - administration & dosage
Sulfuric Acids - adverse effects
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Summary:Cats were used in this study to demonstrate the effect of dilute corrosive drain cleaners upon the esophagus. Sulfuric acid, potassium hydroxide, and sodium hydroxide in less than 10% strength all produced gross and microscopic evidence of severe damage after 30-second exposure. We suggest that presently allowable concentrations of these agents for household use should be banned and cite clinical data on accidental injury in childhood to suggest that "child-proof" packages will not afford much protection.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.53.2.226