Temperature, Mitochondria, and Reye's Syndrome

In Reply.— El-Mallakh raises hypothetical questions about an enhancing effect of fever on mitochondrial damage associated with Reye's syndrome. Our article on aspirin and Reye's syndrome1 emphasized the role of prodromal illness in use of aspirin. Fever was only one of several [See table i...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1983-06, Vol.71 (6), p.985-986
Main Authors: DON BROWN, R., WILSON, JOHN T.
Format: Article
Language:English
Online Access:Get full text
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Summary:In Reply.— El-Mallakh raises hypothetical questions about an enhancing effect of fever on mitochondrial damage associated with Reye's syndrome. Our article on aspirin and Reye's syndrome1 emphasized the role of prodromal illness in use of aspirin. Fever was only one of several [See table in the PDF] prodormal illness events that were different in patients as compared with control subjects. Results of our analysis of the epidemiologic data from the Ohio study reveal a statistically significant higher temperature in those children which Reye's syndrome as compared with unmatched control subjects (Table) as well as in patients and control subjects matched for record temperatures.1
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.71.6.985a