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The proper role of β2-adrenergic agonists in the treatment of children with asthma
β-Adrenergic agonist therapy was associated with increased asthma mortality when high-potency isoproterenol was used in the United Kingdom in the 1960s, and when the β-agonist fenoterol was used increasingly in New Zealand in the 1970s.1-3 Recently, a Canadian epidemiologic study reported an increas...
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Published in: | Pediatrics (Evanston) 1992-10, Vol.90 (4), p.639-640 |
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container_start_page | 639 |
container_title | Pediatrics (Evanston) |
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creator | FURUKAWA, C. T KEMP, J. P SIMONS, F. E. R TINKELMAN, D. G |
description | β-Adrenergic agonist therapy was associated with increased asthma mortality when high-potency isoproterenol was used in the United Kingdom in the 1960s, and when the β-agonist fenoterol was used increasingly in New Zealand in the 1970s.1-3 Recently, a Canadian epidemiologic study reported an increased risk of death with regular use of β-agonists, particularly fenoterol.4 Fenoterol may be uniquely less safe than other β-agonists because of a greater cardiotoxic potential due to less β2 specificity (than terbutaline) and a greater relative dose per actuation.5 The concerns about the safety of β-agonists are linked intimately with the concerns about their effectiveness in asthma therapy. |
doi_str_mv | 10.1542/peds.90.4.639 |
format | article |
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source | EZB Electronic Journals Library |
subjects | Biological and medical sciences Medical sciences Pharmacology. Drug treatments Respiratory system |
title | The proper role of β2-adrenergic agonists in the treatment of children with asthma |
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