New synthetic route to improve uniformity of cell-releasing PEG-based hydrogel carriers

Cell-releasing hydrogel carriers enhance cell-based therapies by improving retention and viability within target tissues. We previously demonstrated tunable cell release from a hydrolytically labile β-thioester-containing polyethylene glycol-based hydrogel. However, the macromer synthesis dependent...

Full description

Saved in:
Bibliographic Details
Published in:MRS communications 2023-10, Vol.13 (5), p.901-906
Main Authors: Green, Mykel, Hicks, Ashley, Sullivan, Taylor, Oliviera, Patience, Venkat, Bhanaviya, Cosgriff-Hernandez, Elizabeth
Format: Article
Language:English
Subjects:
Biomaterials
Characterization and Evaluation of Materials
Chemistry and Materials Science
Materials Engineering
Materials Science
MRS 50th Anniversary Research Letter
Nanotechnology
Polymer Sciences
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cell-releasing hydrogel carriers enhance cell-based therapies by improving retention and viability within target tissues. We previously demonstrated tunable cell release from a hydrolytically labile β-thioester-containing polyethylene glycol-based hydrogel. However, the macromer synthesis dependent on thiol-Michael addition leads to batch variability and heterogeneous hydrogel properties. Herein, we report a new synthetic route with improved control of macromer molecular weight and characterize the resulting hydrogel properties. The resulting PEG dithioester acrylamide (PEGDTEA) hydrogel demonstrates a more controlled synthetic route to generate targeted molecular weights with reduced couplings, creating a more predictable and tunable hydrogel microenvironment for precise cell delivery applications. Graphical abstract Synthesis of thioester containing PEG macromer for more predictable and tunable cell-releasing hydrogels
ISSN:2159-6867
2159-6867
DOI:10.1557/s43579-023-00446-y