Immunohistochemical evaluation of MMP-2, MMP-9 and CD31/microvascular density in squamous cell carcinomas of the floor of the mouth

The aim of this study was to evaluate the immunoexpression of MMP-2, MMP-9 and CD31/microvascular density in squamous cell carcinomas of the floor of the mouth and to correlate the results with demographic, survival, clinical (TNM staging) and histopathological variables (tumor grade, perineural inv...

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Bibliographic Details
Published in:Brazilian dental journal 2013, Vol.24 (1), p.3-9
Main Authors: Monteiro-Amado, Flávio, Castro-Silva, Igor Iuco, Lima, Cristina Jardelino de, Soares, Fernando Augusto, Kowalski, Luiz Paulo, Granjeiro, José Mauro
Format: Article
Language:English
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Summary:The aim of this study was to evaluate the immunoexpression of MMP-2, MMP-9 and CD31/microvascular density in squamous cell carcinomas of the floor of the mouth and to correlate the results with demographic, survival, clinical (TNM staging) and histopathological variables (tumor grade, perineural invasion, embolization and bone invasion). Data from medical records and diagnoses of 41 patients were reviewed. Histological sections were subjected to immunostaining using primary antibodies for human MMP-2, MMP-9 and CD31 and streptavidin-biotin-immunoperoxidase system. Histomorphometric analyses quantified positivity for MMPs (20 fields per slide, 100 points grade, ×200) and for CD31 (microvessels
ISSN:0103-6440
0103-6440
DOI:10.1590/0103-6440201301941