Increased Resolvin E1 Production by Peripheral Blood Mononuclear Cells in Periodontitis Patients: Pilot Study

Abstract This study quantified the production of the pro-resolving agent Resolvin E1 by peripheral blood mononuclear cells (PBMC) from 20 systemically healthy volunteers with and without periodontitis after stimulation with lipopolysaccharide (LPS) from Porphyromonas gingivalis (Pg). Ten periodontit...

Full description

Saved in:
Bibliographic Details
Published in:Brazilian dental journal 2024, Vol.35
Main Authors: Suárez, Lina J., González-Duarte, Wilmer, Torrez-Velasco, Rodrigo, Salinas, Viviana, Roa-Molina, Nelly S., Muñoz, Sindy M., Rodríguez, Luz-Stella, Arce, Roger M., Shibli, Jamil A., Rodríguez-Ciodaro, Adriana
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract This study quantified the production of the pro-resolving agent Resolvin E1 by peripheral blood mononuclear cells (PBMC) from 20 systemically healthy volunteers with and without periodontitis after stimulation with lipopolysaccharide (LPS) from Porphyromonas gingivalis (Pg). Ten periodontitis patients and 10 healthy volunteers (30-50 years old), matched by age and sex, were recruited. Peripheral blood mononuclear cells were isolated and stimulated in culture plates for 24 hours with Pg LPS. Resolvin E1 levels were measured in the supernatants by enzyme-linked immunosorbent assay. Significantly higher production of Resolvin E1 was observed in both groups when stimulated with LPS compared to baseline levels (p
ISSN:0103-6440
1806-4760
DOI:10.1590/0103-6440202405861