Increased levels of plasma IL-1b and BDNF can predict resistant depression patients

• Published in: Revista da Associação Médica Brasileira (1992) 2019-03, Vol.65 (3), p.361-369
• Main Authors: Uint, Luciana, Bastos, Gisele Medeiros, Thurow, Helena Strelow, Borges, Jessica Bassani, Hirata, Thiago Dominguez Crespo, França, João Italo Dias, Hirata, Mario Hiroyuki, Sousa, Amanda Guerra de Moraes Rego
• Format: Magazinearticle
• Language: English
• ISSN: 0104-4230; 1806-9282
• DOI: 10.1590/1806-9282.65.3.361

SUMMARY BACKGROUND: There is no strong evidence on the link between inflammatory profile and pattern of drug treatment response in depressive patients that could result in Coronary Artery Disease occurrence. OBJECTIVE: This study aimed to compare the subclinical atherosclerosis markers, inflammatory profile, and BDNF production in Resistant Depression (RD) or Bipolar Affective Disorder (BAD) patients under conventional treatment. METHODS: The population evaluated was comprised of 34 RD, 43 BAD, and 41 controls. Subclinical atherosclerosis markers were evaluated using ultrasonography, tomography, and exercise stress test. Plasma concentrations of TNFα, IL-1β, IL-6, and BDNF were measured using Luminex100™. The usCRP concentration was measured using turbidimetric immunoassay. IL1B, IL6, and TNFA expression were determined using TaqMan®. For the statistical analysis, the significance level was established at p