Estudo comparativo dos perfis eletroforéticos das proteínas dos líquidos de cistos de astrocitomas e de glioblastomas multiformes

• Published in: Arquivos de neuro-psiquiatria 1966-06, Vol.24 (2), p.97-102
• Main Authors: Spina-França, A., Tenuto, Rolando A., Rocha, A. Gama da
• Format: Article
• Language: English
• ISSN: 0004-282X; 0004-282X
• DOI: 10.1590/S0004-282X1966000200003

Foram analisados os perfis eletroforéticos das proteínas dos líquidos contidos em cistos de astrocitoma (13 casos) e de glioblastoma multiforme (10 casos), sendo os resultados comparados àqueles obtidos nos líquidos de cistos de craniofariogeoma (7 casos) e de coleções subdurais de origem inflamatória (12 casos). Considerando a participação da albumina no perfil protêico eqüivalente à unidade, foi calculada a participação de cada globulina segundo os grupos de casos. Em relação aos dados obtidos para as coleções subdurais, foi verificado que nos LCT de glioblastomas multiformes era maior a participação da globulina gama, comparável à encontrada no LCT de craniofaringeomas e que, nos LCT de astrocitomas, era menor a participação das globulinas alfa-1 e alfa-2. Esta última verificação se mostrou altamente significativa quando comparada à participação dessas globulinas no LCT de astrocitomas e de glioblastomas. Os dados obtidos foram discutidos, permitindo atribuir as diferenças encontradas especialmente a fatôres locais, relacionados à diferente constituição das paredes dos cistos nos astrocitomas e nos glioblastomas multiformes. The differences in the protein composition of cyst fluids from tumors of the central nervous system have been explained by the conditions in which the exchanges between the blood and the cyst fluid occur as well by metabolic aspects related to the malignancy of the tumor cells. In order to explore the influence of these factors the protein fractions from cyst fluids of astrocytoma (13 cases) and from glioblastoma multiforme (10 cases) were studied and the results were compared to those obtained for the protein fractions of two other series of cases: the first was represented by the results obtained for protein fractions of cyst fluids from craneopharyngeoma (7 cases) and, the second, by those concerning to the fluids from inflammatory subdural collections (12 cases). The protein fractions were studied by paper electrophoresis and the results are presented in table 1. The participation of each globulin fraction was calculated and the unit for comparison was the percent value of the albumin fraction for each given case and the mean values and their standard deviations are presented in table 2. The data were discussed and it was possible to show that the differences found are more able to be explained on the basis of the conditions in which the protein exchanges between blood and cyst fluid occur possibly related to the structural char