Experimental model of ultrasound thermotherapy in rats inoculated with Walker-236 tumor

PURPOSE: To develop a model to evaluate the effects of focal pulsed ultrasound (US) waves as a source of heat for treatment of murine subcutaneous implanted Walker tumor. METHODS: An experimental, controlled, comparative study was conducted. Twenty male Wistar rats (160-300 g) randomized in 2 equal...

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Published in:Acta cirúrgica brasileira 2011, Vol.26 (suppl 1), p.53-56
Main Authors: Morano, José Antonio Carlos Otaviano David, Cordeiro, Naylana, Guimarães, Sergio Botelho, Jamacaru, Francisco Vagnaldo Fechine, Moraes Filho, Manoel Odorico de
Format: Article
Language:English
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Summary:PURPOSE: To develop a model to evaluate the effects of focal pulsed ultrasound (US) waves as a source of heat for treatment of murine subcutaneous implanted Walker tumor. METHODS: An experimental, controlled, comparative study was conducted. Twenty male Wistar rats (160-300 g) randomized in 2 equal groups (G-1: Control and G-2: Hyperthermia) were inoculated with Walker-256 carcinosarcoma tumor. After 5 days G-2 rats were submitted to 45ºC hyperthermia. Heat was delivered directly to the tumor by an ultrasound (US) equipment (3 MHz frequency, 1,5W/cm³). Tumor temperature reached 45º C in 3 minutes and was maintained at this level for 5 minutes. Tumor volume was measured on days 5, 8, 11, 14 e 17 post inoculation in both groups. Unpaired t-test was used for comparison. P
ISSN:0102-8650
0102-8650
DOI:10.1590/S0102-86502011000700011