L-alanyl-glutamine pretreatment attenuates acute inflammatory response in children submitted to palatoplasty

• Published in: Acta cirúrgica brasileira 2011, Vol.26 (suppl 1), p.72-76
• Main Authors: Cunha Filho, José Ferreira da, Gonçalves, Isabelle Ivo, Guimarães, Sergio Botelho, Jamacaru, Francisco Vagnaldo Fechine, Garcia, José Huygens Parente, Vasconcelos, Paulo Roberto Leitão de
• Format: Article
• Language: English
• ISSN: 0102-8650; 0102-8650
• DOI: 10.1590/S0102-86502011000700015

PURPOSE: To evaluate the effects of L-alanyl-glutamine (L-Ala-Gln) pretreatment on oxidative stress, glycemic control and inflammatory response in children submitted to palatoplasty. METHODS: Thirty male children scheduled for routine palatoplasty, age range 2-10 years, were randomly assigned to 2 groups (n=15): Group A (saline, control) and Group B (L-Ala-Gln). Group A received normal saline 100 ml, delivered intravenously by infusion pump over 3 hours preceding surgical procedure. Group B was treated with L-Ala-Gln, 20% solution (0.5g/Kg), adding saline to complete 100ml. Peripheral venous blood samples were collected at 5 different time-points: T1- at the beginning of the study, 3 h prior to the surgical procedure; T2- at the end of the infusion (before the surgical procedure), T3- at the end of the surgical procedure, T4- 6 h postoperative and T5- 12 h postoperative. Parameters analyzed included glutathione (GSH), thiobarbituric acid reactive substances (TBARS), glucose, insulin, C-reactive protein (CRP) and interleukin-6 (IL-6). RESULTS: No statistically significant differences were found between groups comparing glucose, insulin, TBARS, GSH and IL-6 levels. However, glucose levels increased (P