Immunohistochemical expression of E-cadherin and CD44v6 in squamous cell carcinomas of the lower lip and tongue

This study analyzed the immunohistochemical expression of E-cadherin and CD44v6 in 15 squamous cell carcinomas (SCCs) of lower lip and 15 SCCs of tongue in order to verify a possible association between these proteins and the anatomic location of the lesion, nodal metastasis and histological grading...

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Bibliographic Details
Published in:Brazilian dental journal 2009, Vol.20 (1), p.64-69
Main Authors: Cruz, Maria Carmen Fontoura Nogueira da, Pereira, Antonio Luiz Amaral, Lopes, Fernanda Ferreira, Nonaka, Cassiano Francisco Weege, Silva, Raimunda Ribeiro da, Freitas, Roseana de Almeida, Souza, Lélia Batista de, Pinto, Leão Pereira
Format: Article
Language:English
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Summary:This study analyzed the immunohistochemical expression of E-cadherin and CD44v6 in 15 squamous cell carcinomas (SCCs) of lower lip and 15 SCCs of tongue in order to verify a possible association between these proteins and the anatomic location of the lesion, nodal metastasis and histological grading of malignancy. The pattern of expression and number of immunopositive cells were evaluated. The results were analyzed with the Fisher's exact test, Mann-Whitney test and Spearman's Correlation Coefficient (r). using the SPSS software 10.0 for Windows. Statistical significance was set at 5% determined for a p-value0.05) in the pattern of expression and number of immunopositive cells for E-cadherin and CD44v6, regarding the anatomical location and nodal metastasis. For the histological grading, low score SCCs showed higher immunopositivity for E-cadherin and CD44v6, both for the pattern of expression and number of immunopositive cells (p
ISSN:0103-6440
0103-6440
DOI:10.1590/S0103-64402009000100011