Enuresis and upper airway obstruction: BNP and ADH hormones behavior before and after airway surgery

• Published in: International Brazilian Journal of Urology 2022-11, Vol.48 (6), p.937-943
• Main Authors: Ribeiro, André, Bastos Netto, José Murillo, Figueiredo, André Avarese de, Cândido, Tarssius Capelo, Guércio, Wilson Benini, Zica, Bruno O.
• Format: Article
• Language: English
• Subjects: Natriuretic Peptide, Brain; Nocturnal Enuresis; Urination Disorders
• ISSN: 1677-5538; 1677-6119
• DOI: 10.1590/s1677-5538.ibju.2022.0313

ABSTRACT Introduction: Upper airway obstruction (UAO) is a common condition in all pediatric population, with a 27% prevalence. Primary monosymptomatic nocturnal enuresis (PMNE) is a condition related to UAO in 8% to 47% of these children. The specific pathophysiological mechanism of this bond is not well understood. Some authors suggest a connection between brain natrituretic peptide (BNP) and anti-diuretic hormone (ADH) during sleep. The aim of this study was to evaluate hormone profile (ADH and BNP) and improvement in dry nights in a sample of children before and after surgical treatment of the UAO. Methods: This is a longitudinal prospective interventionist study in children, 5 to 14 years of age, with UAO and PMNE recruited in a specialty outpatient clinic. Children presenting UAO and PMNE were evaluated with a 30-day dry night diary and blood samples were collected to evaluate ADH and BNP before and after upper airway surgery. Data were analyzed prior to surgery and 90-120 days after surgery. Results: Twenty-one children with a mean age of 9.7 years were included. Mean BNP before surgery was 116.5 ± 126.5 pg/mL and 156.2 ± 112.3 pg/mL after surgery (p