Possible Roxithromycin‐Induced Fulminant Hepatic Failure in a Child

A pediatric formulation of roxithromycin is a relatively new addition to the antibiotic market in Australia. A previously healthy 5‐year‐old boy with no significant medical history was treated with roxithromycin 50 mg twice/day for cough, fever, and anorexia. After completing a 5‐day course of the a...

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Bibliographic Details
Published in:Pharmacotherapy 2001-07, Vol.21 (7), p.867-870
Main Authors: Easton‐Carter, Kylie L., Hardikar, Winita, Smith, Arnold L.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - adverse effects
Biological and medical sciences
Child, Preschool
Drug toxicity and drugs side effects treatment
Humans
Liver Failure - chemically induced
Liver Transplantation
Male
Medical sciences
Pharmacology. Drug treatments
Roxithromycin - adverse effects
Toxicity: digestive system
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Summary:A pediatric formulation of roxithromycin is a relatively new addition to the antibiotic market in Australia. A previously healthy 5‐year‐old boy with no significant medical history was treated with roxithromycin 50 mg twice/day for cough, fever, and anorexia. After completing a 5‐day course of the agent, he developed a nonpruritic, nonurticarial, erythematous, maculopapular, generalized rash and occasional vomiting. Three days later his symptoms included jaundice, dark urine, and pale stools. Laboratory results revealed acute hepatitis, and the patient was admitted to the hospital. His hepatic function continued to deteriorate, so the boy was transferred to a tertiary pediatric hospital. His condition continued to worsen, and 6 days after transfer, he underwent liver transplantation. Clinicians should be aware of potential hepatic complications associated with the use of roxithromycin.
ISSN:0277-0008
1875-9114
DOI:10.1592/phco.21.9.867.34552