Celecoxib‐Induced Erythema Multiforme with Glyburide Cross‐Reactivity

Erythema multiforme is an acute inflammatory skin reaction that often is caused by drugs, especially sulfonamides and their derivatives. Celecoxib, a cyclooxygenase‐2 inhibitor, is a sulfonamide derivative commonly prescribed to treat arthritis in patients who cannot tolerate or who have a contraind...

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Bibliographic Details
Published in:Pharmacotherapy 2002-05, Vol.22 (5), p.637-640
Main Authors: Ernst, Erika J., Egge, Jason A.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Celecoxib
Cross Reactions
Cyclooxygenase Inhibitors - adverse effects
Cyclooxygenase Inhibitors - immunology
Drug Hypersensitivity - immunology
Drug Interactions
Drug toxicity and drugs side effects treatment
Erythema Multiforme - chemically induced
Erythema Multiforme - immunology
Glyburide - adverse effects
Glyburide - immunology
Humans
Hypoglycemic Agents - adverse effects
Hypoglycemic Agents - immunology
Immunoglobulin E - analysis
Male
Medical sciences
Middle Aged
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Pyrazoles
Sulfonamides - adverse effects
Sulfonamides - immunology
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Summary:Erythema multiforme is an acute inflammatory skin reaction that often is caused by drugs, especially sulfonamides and their derivatives. Celecoxib, a cyclooxygenase‐2 inhibitor, is a sulfonamide derivative commonly prescribed to treat arthritis in patients who cannot tolerate or who have a contraindication for taking traditional nonsteroidal antiinflammatory agents. A 57‐year‐old man with a previously undocumented sulfa allergy experienced an allergic skin reaction and had difficulty breathing secondary to throat swelling. His condition was believed to be erythema multiforme associated with the introduction of celecoxib into his drug regimen. His drug therapy was discontinued, but a subsequent reaction occurred when the sulfonamide derivative glyburide was reintroduced. It is important for clinicians to obtain a careful history and perform a thorough medical evaluation in all patients receiving sulfonamides and their derivatives, as a potentially life‐threatening allergic reaction may be prevented.
ISSN:0277-0008
1875-9114
DOI:10.1592/phco.22.8.637.33200